Restless Souls/Technology: Difference between revisions

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DC: pros/cons

Paradox-01

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-===Origin and criticism===
+===Origin===
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 In nature the mycorrhiza accumulated mutations in an unpredicted way. With the silenced fail-safe measures, the mycorrhiza was able to spread out uncontrolled. During the next years it influenced other organisms. This marked the beginning of the BioCrisis. Since then reclamation teams are fighting back the wilderness and WCG is trying to hide their fatal errors from public. Nobody wanted to take the blame.
-Jamie and Prof. Hasegawa searched in the Wilderness Preserves for minimal mutated mycorrhiza to prove that the problem was man-made. On their way into the wilderness Jamie got infected by the fungus. It liquefied her leg tissue. The CDC believed that it was caused by a virus because these symptoms reminded them of Ebola. Hasegawa caught later a tissue samples of Jamie and the fungus in the quarantine zone. He realized that it would need other and better security measures for the Daodan Chryalis to not endanger the environment.
+Jamie and Prof. Hasegawa searched in the Wilderness Preserves for minimal mutated mycorrhiza to prove that the problem was man-made. On their way into the wilderness Jamie got infected by the fungus. It liquefied her leg tissue. The CDC believed that it was caused by a virus because these symptoms reminded them of Ebola. Hasegawa caught later a tissue samples of Jamie and the fungus in the quarantine zone. He realized that it would need other and better security measures for the Daodan Chryalis to [[#Contamination_of_the_ecosystem|not endanger the environment]].
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 Side note: [http://www.youtube.com/watch?v=Xb5ojdciO1E "When the wild wind blows" by Iron Maiden] (up to time code 10:00) might fit for an AMV-styled video of a custom level featuring Jamie and the Prof. in the city and the wilderness. On a second thought it could be also used for the Sturmänderung event.
+===What arguments speak for the Daodan?===
+What arguments could someone use in public to advertise the Daodan?<br>
+'''1) regenerate amputated limbs, faster wound healing, avoid cancer'''<br>
+'''2) compensate slow-paced invention cycles'''<br>
+'''3) compensate lack of natural selection'''<br>
+'''4) compensate human's behavior of putting himself in dangerous situations'''
+'''1) I don't think the first point needs any explanation.'''
+'''2) Some events just happen too fast for Bureaucracy and medical standard procedures.'''
+Without a drastic improvement there could be never a cure of a new deadly pathogen what can kill hours minutes.
+This is the point that Hasegawa would had in mind when he tried to find a cure for Jamie's disease.
+'''3) Many humans aren't longer subject of natural selection which is good in short-term but bad in long-term.'''
+In real life the lack of genetic fitness is somewhat compensated by human's mental fitness which is expressed in applied science, namely: medicine.
+The health care systems (especially in the western world) enable even heavily diseased people to survive and raise children.
+So, when people stay alive no matter their genetically fitness, natural selection can't take place and diseases continue to remain deadly.
+Let's say, if HIV isn't treated at all, wouldn't the whole human race die out?
+No. For instance every 10th European is naturally immune against HIV. So if we had a real plague only the immune people would survive and in the future HIV would be a far smaller problem.
+An historic example of this kind of immunization is the Spanish Flu from 1918 which was the most catastrophic disease in human history so far. The price, immunity, came at the cost of a gigantic mountain of corpses, more than 50 million dead people if you trust the recent numbers.
+With human's current knowledge and possibilities the first outbreak couldn't be prevented but at least it wouldn't kill good portions of the world population.
+With HIV we are facing a dilemma: Either we keep everybody alive at the cost of a reduced life time, a weakened immune systems, social restrictions, discrimination, etc. or we let natural selection happen for the population's sake so gaining immunity. Both options are inacceptable for us humans as emotional beings. We seek for a better solutions but for some reasons we failed so far.
+'''4) Humans often act unwise.'''
+There's an increasing problem with antibiotics. We use them too often to keep ourselves and the livestock healthy. That puts bacteria under [[wikipedia:Evolutionary pressure|evolutionary pressure]]. There are concerns that more ''[[wikipedia:Super_bug_(bacteria)|super bugs]]'' emerge. These multidrug resistant bacteria can't be easily cured. The media-popular MRSA hospital-habituating strain is such a danger.
+Scientists try to come up with methods to reuse old antibiotic or find new ones. However, it can be assumed that the bacteria will also adapt to the new inventions. It's a neverending arms race.
+A alternative to antibiotics are bacteriophages, or for short phages. Russia and Georgia officially uses these bacteria-eating viruses in some [[wikipedia:Phage_therapy|therapies]]. Usually viruses adapt even faster than bacteria but so-called [http://www.nature.com/nature/journal/v450/n7172/full/nature06350.html mutators] can win a biological arms race against phages.
+<!--https://dl.dropboxusercontent.com/u/139715/OniGalore/RS_T_Sources/mutators.zip-->
+If we imagine that all antibiotics will become useless, we would have no other chance to make massive use of phages which again causes further adaptions inside the super bugs.
+===What arguments speak against the Daodan?===
+'''1) drastic change of body'''<br>
+'''2) drastic change of mind'''<br>
+'''3) [[#Contamination_of_the_ecosystem|horizontal gene transfer]]'''
+In order to successfully advertise the Daodan critical points must be rendered baseless. But can that be done or the Daodan really to be feared?
+'''1a) Psychological impact on others.'''
+Imagine someone's skin color changes to sky blue, that won't make you run. "Oh, just another cosplayer?"
+How about an extra pair of arms? "Could be very convenient!"
+Probably the whole appearance will matter.
+At the latest when you run into a group of [https://www.google.de/search?q=Abara&source=lnms&tbm=isch&sa=X&ei=7kC5U4eEBqOJzAO2voGwBA&ved=0CAgQ_AUoAQ&biw=1600&bih=1040 Abara look-alikes], this will stress your sense of safety.
+When you can't distinguish between humans and animals you soon have a fantasy setting similar to some MMO. Cooperation will just depend of people's will to accept or reject a different appearance.
+'''1b) Unwanted autoevolution (lack of control).'''
+You might get traits that ensures better survival but are inconvenient in matter of ascetics. Or you planed to go somewhere and now physically it became impossible.
+With cybernetics you wouldn't have such problem. You would be free to add or remove any feature.
+'''1c) Evolutionary dead ends.'''
+It's said that evolution can go only forward eventually leading in dead ends where no more adaption can take place due to the former adaptions.
+However, the Daodan's analytic nature might circumnavigate this cliff.
+'''2a) I am still myself, the original?'''
+After the Daodan replaced all original cells what happened to the old personality. Was it killed and replaced by a clone's personality?
+That's a very philosophic question. It would be very easy to spread fear with that one if not explained in detail.
+This is similar to teleportation.
+A person enters the teleporter. Information becomes copied and matter destroyer. The information becomes transfered. Then the person becomes rebuilt. If there's anything like a soul was it killed? How can we be sure this is the same person?
+Now let's imagine we teleport everything but the brain from place A to place B. The mind is still at A, isn't it?
+Next, we teleport one brain cell. The brain will still work as it always did when we somehow manage to [[wikipedia:Quantum_entanglement|entangle]] all cell function at B with rest of the brain at A.
+We are looking here at a mind that has physically different residences but it's still only one mind.
+If we repeat this for every brain cells, there would be always just one mind at any time, also when 50% is at A and 50% at B.
+After we completed this special teleportation we would have no doubt that the person is truly the person that went into the teleporter chamber.
+Now let's look at cell growth/death a bit.
+There's speculation on-going on how much cells die every second in the human body. The numbers range from many thousands to few millions.
+The important point for us is that the body and hence brain is in constant state of change.
+Cells divide and die everyday and we don't ask ourself "are we still the same?"
+Apparently we are okay with that. Cells die, some get replaced.
+So, for the Daodan we can imagine that our brain cells get replaced one by one whereby normal and upgraded cells are always linked.
+The mind remains original at any time. We are just changing to anther hardware.
+'''2b) Does the Daodan changes the personality?'''
+The DC enhances the body. It has no other intention.
+Probably a change in personality would be caused indirectly.
+An aggressive person might outlive his strategy and become more aggressive because negative consequences would have a smaller impact on him.
+'''3) [[#Contamination_of_the_ecosystem|Horizontal gene transfer.]]'''
+Why is this something bad? The Daodan gives humans an incredible huge advantage against all other lifeforms.
+If the Daodan mechanisms are shared with the rest of nature, hyperevolution will take place everywhere making it harder to adapt to bacteria and viruses again.
 ===Explanation attempt of the biological dimension===
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 Thus the type of damage becomes analyzed and therefore the Daodan requires a sensor system.
-In nature, “higher lifeforms” evolved  by following – among other concepts – specialization and socialization. Those find their expression on one hand in different cell types – therefore multicellular organism – and on other hand in all kinds of symbiosis. So, for a hyperevolved organism, it wound be understandable if it work more intensely by those concepts.
+In nature, "higher lifeforms" evolved  by following – among other concepts – specialization and socialization. Those find their expression on one hand in different cell types – therefore multicellular organism – and on other hand in all kinds of symbiosis. So, for a hyperevolved organism, it wound be understandable if it work more intensely by those concepts.
 A body realizes damage or harmful influences by stimuli. To detect all kind of stimuli, much space is surely needed.
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 Für die genauen Entscheidungsalgorithmen und ihrer physischen Strukturen zur Mutationsfindung müssten wir wohl Hasegawa fragen. ;-)
-Abhängig vom Ziel – menschliches Genom, Mikrobiom, ihrer beider Epigenome, oder sogar Organell-Genome (wie Mitochondrien und Plastiden sie haben) – müssen ein paar unterschiedliche „Vektoren“ (unter anderem Viren) verfügbar sein um die Mutation zu transportieren. (Um Diskussionen zu vereinfachen, mag man vielleicht auf den Begriff [http://www.cs.uni-duesseldorf.de/AG/AlgBio/Research/Research_in_the_News/Dokumente/RM28015.pdf Holobiont], Gesammtheit aller Symbionten, und Hologenom, Gesamtheit aller Symbionten-Genome, zurückgreifen.
+Abhängig vom Ziel – menschliches Genom, Mikrobiom, ihrer beider Epigenome, oder sogar Organell-Genome (wie Mitochondrien und Plastiden sie haben) – müssen ein paar unterschiedliche "Vektoren" (unter anderem Viren) verfügbar sein um die Mutation zu transportieren. (Um Diskussionen zu vereinfachen, mag man vielleicht auf den Begriff  Holobiont, Gesammtheit aller Symbionten, und Hologenom, Gesamtheit aller Symbionten-Genome, zurückgreifen.
 Trotzdem ist es schwer zu glauben, dass die Daodan vollkommen alleine im Stande wäre passende Mutationen zu erzeugen. Es ist vielleicht glaubwürdiger, wenn die Daodan auf „genetische Bausteine“ zurückgreift, die Basisinformationen für schnelle Regeneration, Resistenzen, unterschiedliche Stoffwechsel, und so weiter enthalten. Vielleicht kann die Chrysalis auch bereits existierendes mikrobisches Genmaterial verwenden: ein Mensch hat immerhin 23 000 Gene (500 000 bis 1 000 000 Proteine durch alternatives Splißen) aber sein Mikrobiom hat mehr als 5 Millionen Gene/Proteine.
-Das Mikrobiom ist von Menschen zu Mensch sehr unterschiedlich und würde die Daodan-Massenproduktion sicherlich nicht einfacher machen. Aber nach mehr als 15 weiteren Jahren sollte das Syndikat eine Weg gefunden haben den Herstellungsprozess zu vereinfachen. Diese zweite Generation würde durch sogenannte Level-Null-Stammzellen unabhängig vom Geschlecht des Wirts und der Zusammensetzung des Mikrobiom sein. Diese Zellen würden jede kompatible Symbiontenzelle zum Ziel haben und nach einer „Konfiguration“ (in welcher sie überflüssiges genetisches Material auflösen) zu klassischen Stammzellen und Mikroben werden.
+Das Mikrobiom ist von Menschen zu Mensch sehr unterschiedlich und würde die Daodan-Massenproduktion sicherlich nicht einfacher machen. Aber nach mehr als 15 weiteren Jahren sollte das Syndikat eine Weg gefunden haben den Herstellungsprozess zu vereinfachen. Diese zweite Generation würde durch sogenannte Level-Null-Stammzellen unabhängig vom Geschlecht des Wirts und der Zusammensetzung des Mikrobiom sein. Diese Zellen würden jede kompatible Symbiontenzelle zum Ziel haben und nach einer "Konfiguration" (in welcher sie überflüssiges genetisches Material auflösen) zu klassischen Stammzellen und Mikroben werden.
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