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Depending on the target – human Daodan genome, Daodan microbiome, both their epigenomes, or even organelle genomes (like mitochondria and plastids have) – a few different “vectors” (e.g. viruses) need to be available to transport the mutation. (For ease of discussion, one might wish to use the terms holobiont -- the collective symbionts, and hologenome -- the sum of the symbionts' genomes.) | Depending on the target – human Daodan genome, Daodan microbiome, both their epigenomes, or even organelle genomes (like mitochondria and plastids have) – a few different “vectors” (e.g. viruses) need to be available to transport the mutation. (For ease of discussion, one might wish to use the terms holobiont -- the collective symbionts, and hologenome -- the sum of the symbionts' genomes.) | ||
However, it's hard to believe that the Daodan would be able to come up with fitting mutations completely by its own. It seems more likely to me that it draws on “genetic building blocks” holding basic information for fast regeneration, resistances, different metabolisms, and so on. Maybe the Daodan can also make use of already existing genetic material of the microbes: after all, a human just has 23,000 genes (500,000 up to 1,000,000 proteins through alternative splicing), while his microbiome has more than [https://www.hsph.harvard.edu/news/press-releases/human-microbiome-project/ 5 million] genes/proteins. | However, it's hard to believe that the Daodan would be able to come up with fitting mutations completely by its own. It seems more likely to me that it draws on “genetic building blocks” holding basic information for fast regeneration, resistances, different metabolisms, and so on. Maybe the Daodan can also make use of already existing genetic material of the microbes: after all, a human just has 23,000 genes (500,000 up to 1,000,000 proteins through alternative splicing), while his microbiome has more than [https://web.archive.org/web/20200711115107/https://www.hsph.harvard.edu/news/press-releases/human-microbiome-project/ 5 million] genes/proteins. | ||
The microbiome is very different among humans and would surely make the Daodan's mass production no easy task. But after more than 15 years, the Syndicate should have accomplished a way to simplify the process. This second generation would be independent from the host's sex (XX / YX chromosomes) and the microbiome's composition by providing level-zero stem cells. These can target any compatible symbiont cell and then do a “configuration” (whereby they dissolve the unnecessary genetic material) to become ''classic'' daodanized stem cells and microbes. | The microbiome is very different among humans and would surely make the Daodan's mass production no easy task. But after more than 15 years, the Syndicate should have accomplished a way to simplify the process. This second generation would be independent from the host's sex (XX / YX chromosomes) and the microbiome's composition by providing level-zero stem cells. These can target any compatible symbiont cell and then do a “configuration” (whereby they dissolve the unnecessary genetic material) to become ''classic'' daodanized stem cells and microbes. | ||